FOCUS ON FIVE STORY LINES
1 A rare rematch Peyton will be up against it
Denver at Seattle is the first regular-season rematch of a Super Bowl since 1997 and only the sixth ever. Peyton Manning gets back Wes Welker from a drug suspension.
2 Trouble meets trouble Saints desperate for victory
With the Vikings ranking last in passing offense, the winless Saints can have some confidence they will get off the schneid.
3 Cardinals seek to make statement Quarterback is an issue
Arizona, which plays host to San Francisco, can assert itself in the NFC West. The Cards beat the Giants with backup QB Drew Stanton. The 49ers aren't the Giants, and Carson Palmer's status is iffy.
4 NFC North identity struggle Who are these guys anyway?
Detroit went from sensational to awful in a span of a week. Green Bay went the other way — but only after falling into a big hole against the Jets in Game 2. They meet Sunday; the Pack has lost in Detroit only twice in the past decade.
5 Will DeSean miss his chance? Maybe revenge, maybe not
Everyone associated with the Redskins expects wide receiver DeSean Jackson to play against the team that cut him, the Eagles, though he has a shoulder injury. Washington coach Jay Gruden is hopeful.